Developing surgical sutures with adjustable bioactivities is essential for diverse surgical interventions. However, adversely affecting their mechanical integrity, biocompatibility, and bioactivity poses a significant challenge. Herein, we present a silk‐based bioactive suture that incorporates silver nanoparticles (AgNPs) and curcumin (Cur) via a dual in situ integration strategy. This innovative approach leverages the unique reactive groups and molecular interactions inherent in silk to facilitate the in situ reduction of AgNPs and the conformal loading of Cur. Extensive in vitro and in vivo evaluations confirm the suture's multifunctionality. This suture excels in real‐time wound monitoring due to its sensitive colorimetric pH response. It is biocompatible and offers strong antibacterial and anti‐inflammatory benefits, essential for infection prevention and inflammation control postsurgery. Moreover, it actively aids wound healing by promoting angiogenesis and collagen deposition, vital for effective tissue repair. This approach provides a promising foundation for creating advanced smart sutures with on‐demand bioactivities and on‐site monitoring capabilities.
https://doi.org/10.1002/idm2.70025
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